The BpeEF-OprC Efflux Pump Is Responsible for Widespread Trimethoprim Resistance in Clinical and Environmental Burkholderia pseudomallei Isolates

Trimethoprim-sulfamethoxazole (co-trimoxazole) is the primary drug used for oral eradication therapy of Burkholderia pseudomallei infections (melioidosis). Here, we demonstrate that trimethoprim resistance is widespread in clinical and environmental isolates from northeast Thailand and northern Aust...

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Autori principali: Podnecky, Nicole L., Wuthiekanun, Vanaporn, Peacock, Sharon J., Schweizer, Herbert P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754293/
https://ncbi.nlm.nih.gov/pubmed/23817379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00660-13
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