Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

RUNX1 is generally considered a tumor suppressor in myeloid neoplasms. Inactivating RUNX1 mutations have frequently been found in patients with myelodysplastic syndrome (MDS) and cytogenetically normal acute myeloid leukemia (AML). However, no somatic RUNX1 alteration was found in AMLs with leukemog...

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Detalhes bibliográficos
Main Authors: Goyama, Susumu, Schibler, Janet, Cunningham, Lea, Zhang, Yue, Rao, Yalan, Nishimoto, Nahoko, Nakagawa, Masahiro, Olsson, Andre, Wunderlich, Mark, Link, Kevin A., Mizukawa, Benjamin, Grimes, H. Leighton, Kurokawa, Mineo, Liu, P. Paul, Huang, Gang, Mulloy, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754260/
https://ncbi.nlm.nih.gov/pubmed/23979164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68557
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