The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1–RUNX1T1

RUNX1 is a member of RUNX transcription factors and plays important roles in hematopoiesis. Disruption of RUNX1 activity has been implicated in the development of hematopoietic neoplasms. Chromosomal translocations involving the RUNX1 gene are associated with several types of leukemia, including acu...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yonezawa, Taishi, Takahashi, Hirotaka, Shikata, Shiori, Liu, Xiaoxiao, Tamura, Moe, Asada, Shuhei, Fukushima, Tsuyoshi, Fukuyama, Tomofusa, Tanaka, Yosuke, Sawasaki, Tatsuya, Kitamura, Toshio, Goyama, Susumu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535027/
https://ncbi.nlm.nih.gov/pubmed/28536267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785675
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