The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1–RUNX1T1

RUNX1 is a member of RUNX transcription factors and plays important roles in hematopoiesis. Disruption of RUNX1 activity has been implicated in the development of hematopoietic neoplasms. Chromosomal translocations involving the RUNX1 gene are associated with several types of leukemia, including acu...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Yonezawa, Taishi, Takahashi, Hirotaka, Shikata, Shiori, Liu, Xiaoxiao, Tamura, Moe, Asada, Shuhei, Fukushima, Tsuyoshi, Fukuyama, Tomofusa, Tanaka, Yosuke, Sawasaki, Tatsuya, Kitamura, Toshio, Goyama, Susumu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
Onderwerpen:
Protein Synthesis and Degradation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535027/
https://ncbi.nlm.nih.gov/pubmed/28536267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785675
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