Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological agin...

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Udgivet i:Nat Commun
Main Authors: Fujino, Takeshi, Goyama, Susumu, Sugiura, Yuki, Inoue, Daichi, Asada, Shuhei, Yamasaki, Satoshi, Matsumoto, Akiko, Yamaguchi, Kiyoshi, Isobe, Yumiko, Tsuchiya, Akiho, Shikata, Shiori, Sato, Naru, Morinaga, Hironobu, Fukuyama, Tomofusa, Tanaka, Yosuke, Fukushima, Tsuyoshi, Takeda, Reina, Yamamoto, Keita, Honda, Hiroaki, Nishimura, Emi K., Furukawa, Yoichi, Shibata, Tatsuhiro, Abdel-Wahab, Omar, Suematsu, Makoto, Kitamura, Toshio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988019/
https://ncbi.nlm.nih.gov/pubmed/33758188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22053-y
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