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The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies

The spike (S) protein of the recently emerged human Middle East respiratory syndrome coronavirus (MERS-CoV) mediates infection by binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). Here we mapped the receptor binding domain in the S protein to a 231-amino-acid fragment (residues 358 to...

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Autori principali: Mou, Huihui, Raj, V. Stalin, van Kuppeveld, Frank J. M., Rottier, Peter J. M., Haagmans, Bart L., Bosch, Berend Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754068/
https://ncbi.nlm.nih.gov/pubmed/23785207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01277-13
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