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Molecular Basis of the Essential S Phase Function of the Rad53 Checkpoint Kinase
The essential yeast kinases Mec1 and Rad53, or human ATR and Chk1, are crucial for checkpoint responses to exogenous genotoxic agents, but why they are also required for DNA replication in unperturbed cells remains poorly understood. Here we report that even in the absence of DNA-damaging agents, th...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753913/ https://ncbi.nlm.nih.gov/pubmed/23754745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00474-13 |
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