Molecular Basis of the Essential S Phase Function of the Rad53 Checkpoint Kinase

The essential yeast kinases Mec1 and Rad53, or human ATR and Chk1, are crucial for checkpoint responses to exogenous genotoxic agents, but why they are also required for DNA replication in unperturbed cells remains poorly understood. Here we report that even in the absence of DNA-damaging agents, th...

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Detalhes bibliográficos
Main Authors: Hoch, Nicolas C., Chen, Eric S.-W., Buckland, Robert, Wang, Shun-Chung, Fazio, Alessandro, Hammet, Andrew, Pellicioli, Achille, Chabes, Andrei, Tsai, Ming-Daw, Heierhorst, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753913/
https://ncbi.nlm.nih.gov/pubmed/23754745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00474-13
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