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Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast

Phosphorylation of histone H2A or H2AX is an early and sensitive marker of DNA damage in eukaryotic cells, although mutation of the conserved damage-dependent phosphorylation site is well tolerated. Here, we show that H2A phosphorylation is required for cell-cycle arrest in response to DNA damage at...

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Detalhes bibliográficos
Main Authors: Hammet, Andrew, Magill, Christine, Heierhorst, Jörg, Jackson, Stephen P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1973948/
https://ncbi.nlm.nih.gov/pubmed/17721446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401036
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