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Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
Cellular growth signals stimulate anabolic processes. The mechanistic target of rapamycin complex 1 (mTORC1) is a protein kinase that senses growth signals to regulate anabolic growth and proliferation. Activation of mTORC1 led to the acute stimulation of metabolic flux through the de novo pyrimidin...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753690/ https://ncbi.nlm.nih.gov/pubmed/23429703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228792 |
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