Multiplexed Microcolumn-Based Process for Efficient Selection of RNA Aptamers

[Image: see text] We describe a reusable microcolumn and process for the efficient discovery of nucleic acid aptamers for multiple target molecules. The design of our device requires only microliter volumes of affinity chromatography resin—a condition that maximizes the enrichment of target-binding...

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Hauptverfasser: Latulippe, David R., Szeto, Kylan, Ozer, Abdullah, Duarte, Fabiana M., Kelly, Christopher V., Pagano, John M., White, Brian S., Shalloway, David, Lis, John T., Craighead, Harold G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753675/
https://ncbi.nlm.nih.gov/pubmed/23398198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac400105e
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