Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause Regions

The four-subunit Negative Elongation Factor (NELF) is a major regulator of RNA Polymerase II (Pol II) pausing. The subunit NELF-E contains a conserved RNA Recognition Motif (RRM) and is proposed to facilitate Poll II pausing through its association with nascent transcribed RNA. However, conflicting...

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Detalhes bibliográficos
Main Authors: Pagano, John M., Kwak, Hojoong, Waters, Colin T., Sprouse, Rebekka O., White, Brian S., Ozer, Abdullah, Szeto, Kylan, Shalloway, David, Craighead, Harold G., Lis, John T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894171/
https://ncbi.nlm.nih.gov/pubmed/24453987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004090
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