Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[(18)F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([(18)F]-FMISO)

We report an automated synthesis of [18F]-FMISO utilizing a prototype microfluidic radiochemistry module. The instrument allows for production of the tracer with 58% ± 2% (11 runs) decay corrected yield. Total time of production, including synthesis and purification averages 60 minutes. Use of the m...

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Detalhes bibliográficos
Main Authors: Yokell, Daniel L, Leece, Alicia K, Lebedev, Artem, Miraghaie, Reza, Ball, Carroll E., Zhang, Jianzhong, Kolb, Hartmuth, Elizarov, Arkadij, Mahmood, Umar
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753664/
https://ncbi.nlm.nih.gov/pubmed/22871433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2012.05.022
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