Repurposing (18)F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy

Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene transduction in tumours. The clinical development of NTR-based GDEPT has, in part...

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書目詳細資料
發表在:Theranostics
Main Authors: Ruiz de Garibay, Gorka, García de Jalón, Elvira, Stigen, Endre, Lund, Kjetil B, Popa, Mihaela, Davidson, Ben, Safont, Mireia Mayoral, Rygh, Cecilie B., Espedal, Heidi, Barrett, Torill M, Haug, Bengt Erik, McCormack, Emmet
格式: Artigo
語言:Inglês
出版: Ivyspring International Publisher 2021
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058731/
https://ncbi.nlm.nih.gov/pubmed/33897898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.55092
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