Repurposing (18)F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy

Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene transduction in tumours. The clinical development of NTR-based GDEPT has, in part...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Ruiz de Garibay, Gorka, García de Jalón, Elvira, Stigen, Endre, Lund, Kjetil B, Popa, Mihaela, Davidson, Ben, Safont, Mireia Mayoral, Rygh, Cecilie B., Espedal, Heidi, Barrett, Torill M, Haug, Bengt Erik, McCormack, Emmet
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058731/
https://ncbi.nlm.nih.gov/pubmed/33897898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.55092
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