Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In case of GDEPT, since NTR is not naturally present in mammalian cells, the prodrug...

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Vydáno v:PLoS One
Hlavní autoři: Vorobyeva, Anzhelika G., Stanton, Michael, Godinat, Aurélien, Lund, Kjetil B., Karateev, Grigory G., Francis, Kevin P., Allen, Elizabeth, Gelovani, Juri G., McCormack, Emmet, Tangney, Mark, Dubikovskaya, Elena A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482324/
https://ncbi.nlm.nih.gov/pubmed/26110789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131037
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