Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks

The mobility of damaged chromatin regions in the nucleus may affect the probability of mis-repair. In this work, live-cell observation and distance tracking of GFP-tagged DNA damage response protein MDC1 was used to study the random-walk behaviour of chromatin domains containing radiation-induced DN...

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Main Authors: Girst, S., Hable, V., Drexler, G. A., Greubel, C., Siebenwirth, C., Haum, M., Friedl, A. A., Dollinger, G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753591/
https://ncbi.nlm.nih.gov/pubmed/23979012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02511
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