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PUMA and BIM Are Required for Oncogene Inactivation–Induced Apoptosis
The clinical efficacy of tyrosine kinase inhibitors supports the dependence of distinct subsets of cancers on specific driver mutations for survival, a phenomenon called “oncogene addiction.” We demonstrate that PUMA and BIM are the key apoptotic effectors of tyrosine kinase inhibitors in breast can...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753585/ https://ncbi.nlm.nih.gov/pubmed/23532334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003483 |
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