Cyclin D1 Determines Estrogen Signaling in the Mammary Gland In Vivo

The CCND1 gene, which is frequently overexpressed in cancers, encodes the regulatory subunit of a holoenzyme that phosphorylates the retinoblastoma protein. Although it is known that cyclin D1 regulates estrogen receptor (ER)α transactivation using heterologous reporter systems, the in vivo biologic...

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Autors principals: Casimiro, Mathew C., Wang, Chenguang, Li, Zhiping, Di Sante, Gabriele, Willmart, Nicole E., Addya, Sankar, Chen, Lei, Liu, Yang, Lisanti, Michael P., Pestell, Richard G.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753428/
https://ncbi.nlm.nih.gov/pubmed/23864650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1065
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