Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool

DACH1 abundance is reduced in human malignancies, including breast cancer. Herein DACH1 was detected among multipotent fetal mammary stem cells in the embryo, among mixed lineage precursors, and in adult basal cells and (ERα(+)) luminal progenitors. Dach1 gene deletion at 6 weeks in transgenic mice...

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Publié dans:Stem Cell Reports
Auteurs principaux: Jiao, Xuanmao, Li, Zhiping, Wang, Min, Katiyar, Sanjay, Di Sante, Gabriele, Farshchian, Mehdi, South, Andrew P., Cocola, Cinzia, Colombo, Daniele, Reinbold, Rolland, Zucchi, Ileana, Wu, Kongming, Tabas, Ira, Spike, Benjamin T., Pestell, Richard G.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335505/
https://ncbi.nlm.nih.gov/pubmed/30554919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.11.010
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