Effect of rpoB Mutations Conferring Rifampin Resistance on Fitness of Mycobacterium tuberculosis

Rifampin is a major drug used in the treatment of tuberculosis infections, and increasing rifampin resistance represents a worldwide clinical problem. Resistance to rifampin is caused by mutations in the rpoB gene, encoding the β-subunit of RNA polymerase. We examined the effect of three different r...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Mariam, Deneke H., Mengistu, Yohannes, Hoffner, Sven E., Andersson, Dan I.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2004
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC375340/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15047531/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.4.1289-1294.2004
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