Effect of rpoB Mutations Conferring Rifampin Resistance on Fitness of Mycobacterium tuberculosis

Rifampin is a major drug used in the treatment of tuberculosis infections, and increasing rifampin resistance represents a worldwide clinical problem. Resistance to rifampin is caused by mutations in the rpoB gene, encoding the β-subunit of RNA polymerase. We examined the effect of three different r...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Mariam, Deneke H., Mengistu, Yohannes, Hoffner, Sven E., Andersson, Dan I.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2004
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC375340/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15047531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.4.1289-1294.2004
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