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Relationship between Antiviral Activity and Host Toxicity: Comparison of the Incorporation Efficiencies of 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine-Triphosphate Analogs by Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Human Mitochondrial DNA Polymerase
Emtricitabine [(−)FTC; (−)-β-l-2′-3′-dideoxy-5-fluoro-3′-thiacytidine] is an oxathiolane nucleoside analog recently approved by the Food and Drug Administration for the treatment of human immunodeficiency virus (HIV). Structurally, (−)FTC closely resembles lamivudine [(−)3TC] except that the former...
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Prif Awduron: | , , , , , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
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American Society for Microbiology
2004
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC375312/ https://ncbi.nlm.nih.gov/pubmed/15047533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.4.1300-1306.2004 |
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