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Relationship between Antiviral Activity and Host Toxicity: Comparison of the Incorporation Efficiencies of 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine-Triphosphate Analogs by Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Human Mitochondrial DNA Polymerase

Emtricitabine [(−)FTC; (−)-β-l-2′-3′-dideoxy-5-fluoro-3′-thiacytidine] is an oxathiolane nucleoside analog recently approved by the Food and Drug Administration for the treatment of human immunodeficiency virus (HIV). Structurally, (−)FTC closely resembles lamivudine [(−)3TC] except that the former...

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Detaylı Bibliyografya
Asıl Yazarlar: Feng, Joy Y., Murakami, Eisuke, Zorca, Suzana M., Johnson, Allison A., Johnson, Kenneth A., Schinazi, Raymond F., Furman, Phillip A., Anderson, Karen S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2004
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC375312/
https://ncbi.nlm.nih.gov/pubmed/15047533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.4.1300-1306.2004
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