Mycobacterium tuberculosis DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity

Genome studies suggest that DNA gyrase is the sole type II topoisomerase and likely the unique target of quinolones in Mycobacterium tuberculosis. Despite the emerging importance of quinolones in the treatment of mycobacterial disease, the slow growth and high pathogenicity of M. tuberculosis have p...

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Autori principali: Aubry, Alexandra, Pan, Xiao-Su, Fisher, L. Mark, Jarlier, Vincent, Cambau, Emmanuelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC375300/
https://ncbi.nlm.nih.gov/pubmed/15047530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.4.1281-1288.2004
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