Mycobacterium tuberculosis DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity

Genome studies suggest that DNA gyrase is the sole type II topoisomerase and likely the unique target of quinolones in Mycobacterium tuberculosis. Despite the emerging importance of quinolones in the treatment of mycobacterial disease, the slow growth and high pathogenicity of M. tuberculosis have p...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Aubry, Alexandra, Pan, Xiao-Su, Fisher, L. Mark, Jarlier, Vincent, Cambau, Emmanuelle
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC375300/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15047530/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.4.1281-1288.2004
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