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D-optimal designs for parameter estimation for indirect pharmacodynamic response models
This report generates efficient experimental designs (dose, sampling times) for parameter estimation for four basic physiologic indirect pharmacodynamic response (IDR) models. The principles underlying IDR models and their response patterns have been well described. Each IDR model explicitly contain...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752677/ https://ncbi.nlm.nih.gov/pubmed/19904585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-009-9135-7 |
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