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Optimal Design for Estimating Parameters of the 4-Parameter Hill Model

Many drug concentration-effect relationships are described by nonlinear sigmoid models. The 4-parameter Hill model, which belongs to this class, is commonly used. An experimental design is essential to accurately estimate the parameters of the model. In this report we investigate properties of D-opt...

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Detalhes bibliográficos
Main Authors: Khinkis, Leonid A., Levasseur, Laurence, Faessel, Hélène, Greco, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: International Hormesis Society 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656127/
https://ncbi.nlm.nih.gov/pubmed/19330140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15401420390249925
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