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D-optimal designs for parameter estimation for indirect pharmacodynamic response models
This report generates efficient experimental designs (dose, sampling times) for parameter estimation for four basic physiologic indirect pharmacodynamic response (IDR) models. The principles underlying IDR models and their response patterns have been well described. Each IDR model explicitly contain...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752677/ https://ncbi.nlm.nih.gov/pubmed/19904585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-009-9135-7 |
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