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D-optimal designs for parameter estimation for indirect pharmacodynamic response models

This report generates efficient experimental designs (dose, sampling times) for parameter estimation for four basic physiologic indirect pharmacodynamic response (IDR) models. The principles underlying IDR models and their response patterns have been well described. Each IDR model explicitly contain...

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Bibliografski detalji
Glavni autori: Khinkis, Leonid A., Krzyzanski, Wojciech, Jusko, William J., Greco, William R.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752677/
https://ncbi.nlm.nih.gov/pubmed/19904585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-009-9135-7
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