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D-optimal designs for parameter estimation for indirect pharmacodynamic response models

This report generates efficient experimental designs (dose, sampling times) for parameter estimation for four basic physiologic indirect pharmacodynamic response (IDR) models. The principles underlying IDR models and their response patterns have been well described. Each IDR model explicitly contain...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Khinkis, Leonid A., Krzyzanski, Wojciech, Jusko, William J., Greco, William R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752677/
https://ncbi.nlm.nih.gov/pubmed/19904585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-009-9135-7
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