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β-Turn Sequences Promote Stability of Peptide Substrates for Kinases within the Cytosolic Environment
A strategy was developed to extend the lifetime of an peptide-based substrate for Abl kinase in the cytosolic environment. Small β-turn structures were added to the peptide’s N-terminus to block entry into peptidase catalytic sites. The influence of the size of the β-turn and two covalent cross-link...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2013
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752283/ https://ncbi.nlm.nih.gov/pubmed/23785707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3an00874f |
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