Development of β-Hairpin Peptides for the Measurement of SCF-Family E3 Ligase Activity in Vitro via Ornithine Ubiquitination

[Image: see text] Regulation of the ubiquitin–proteasome system (UPS) to treat select types of cancer has become a popular area of drug discovery research. The FDA approval of proteasome inhibitors Bortezomib and Carfilzomib in the treatment of multiple myeloma has led to an increased need for chemi...

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Veröffentlicht in:ACS Omega
Hauptverfasser: Houston, Kaiulani M., Melvin, Adam T., Woss, Gregery S., Fayer, Effrat L., Waters, Marcey L., Allbritton, Nancy L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377275/
https://ncbi.nlm.nih.gov/pubmed/28393136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00109
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