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Identification of a p53-based portable degron based on the MDM2-p53 binding region

In recent years the ubiquitin proteasome system (UPS) has garnered increasing interest as a target for chemotherapeutics. Due to the success of the proteasome inhibitors Bortezomib and Carfilzomib in the treatment of multiple myeloma, several new compounds have been developed to target E3 ubiquitin...

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Detalhes bibliográficos
Publicado no:Analyst
Main Authors: Melvin, Adam T., Dumberger, Lukas D., Woss, Gregery S., Waters, Marcey L., Allbritton, Nancy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042837/
https://ncbi.nlm.nih.gov/pubmed/26456660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5an01429h
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