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T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
IgG2a is known to be the most efficient antibody isotype for viral clearance. Here, we demonstrate a unique pathway of B-cell activation, leading to IgG2a production, and involving synergistic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), and IFNγ receptors on B cells. This...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752276/ https://ncbi.nlm.nih.gov/pubmed/23922396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312348110 |
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