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T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

IgG2a is known to be the most efficient antibody isotype for viral clearance. Here, we demonstrate a unique pathway of B-cell activation, leading to IgG2a production, and involving synergistic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), and IFNγ receptors on B cells. This...

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Autors principals: Rubtsova, Kira, Rubtsov, Anatoly V., van Dyk, Linda F., Kappler, John W., Marrack, Philippa
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752276/
https://ncbi.nlm.nih.gov/pubmed/23922396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312348110
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