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Prevalent mechanism of membrane bridging by synaptotagmin-1

Synaptotagmin-1 functions as a Ca(2+) sensor in neurotransmitter release through its two C(2) domains (the C(2)A and C(2)B domain). The ability of synaptotagmin-1 to bridge two membranes is likely crucial for its function, enabling cooperation with the soluble N-ethylmaleimide sensitive factor adapt...

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Autori principali: Seven, Alpay B., Brewer, Kyle D., Shi, Liang, Jiang, Qiu-Xing, Rizo, Josep
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752263/
https://ncbi.nlm.nih.gov/pubmed/23918375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310327110
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