Hippo pathway effector Yap promotes cardiac regeneration

The adult mammalian heart has limited potential for regeneration. Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the neonatal heart can regenerate owing to sustained cardiomyocyte proliferation. Identification of critical regulators of cardiomy...

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Hlavní autoři: Xin, Mei, Kim, Yuri, Sutherland, Lillian B., Murakami, Masao, Qi, Xiaoxia, McAnally, John, Porrello, Enzo R., Mahmoud, Ahmed I., Tan, Wei, Shelton, John M., Richardson, James A., Sadek, Hesham A., Bassel-Duby, Rhonda, Olson, Eric N.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752208/
https://ncbi.nlm.nih.gov/pubmed/23918388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313192110
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