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Response-Adaptive Decision-Theoretic Trial Design: Operating Characteristics and Ethics

Adaptive randomization is used in clinical trials to increase statistical efficiency. In addition, some clinicians and researchers believe that using adaptive randomization leads necessarily to more ethical treatment of subjects in a trial. We develop Bayesian, decision-theoretic, clinical trial des...

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Bibliographic Details
Main Authors: Lipsky, Ari M., Lewis, Roger J.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751997/
https://ncbi.nlm.nih.gov/pubmed/23558674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5807
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