Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication

BACKGROUND: Claudication secondary to peripheral artery disease (PAD) is associated with substantial functional impairment. Phosphodiesterase (PDE) inhibitors have been shown to increase walking performance in these patients. K-134 is a selective PDE 3 inhibitor being developed as a potential treatm...

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Detalhes bibliográficos
Main Authors: Lewis, Roger J, Connor, Jason T, Teerlink, John R, Murphy, James R, Cooper, Leslie T, Hiatt, William R, Brass, Eric P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126735/
https://ncbi.nlm.nih.gov/pubmed/21612611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-12-134
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