PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling

INTRODUCTION: The chemokine CXCL12, also known as SDF-1, and its receptor, CXCR4, are overexpressed in prostate cancers and in animal models of prostate-specific PTEN deletion, but their regulation is poorly understood. Loss of the tumor suppressor PTEN (phosphatase and tensin homolog) is frequently...

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Bibliografiset tiedot
Päätekijät: Conley-LaComb, M Katie, Saliganan, Allen, Kandagatla, Pridvi, Chen, Yong Q, Cher, Michael L, Chinni, Sreenivasa R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2013
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751767/
https://ncbi.nlm.nih.gov/pubmed/23902739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-85
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