Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis

BACKGROUND: The CXCL12/CXCR4 axis transactivates HER2 and promotes intraosseous tumor growth. To further explore the transactivation of HER2 by CXCL12, we investigated the role of small GTP protein G(αi2) in Src and HER2 phosphorylation in lipid raft membrane microdomains and the significance of CXC...

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Bibliografiske detaljer
Udgivet i:Mol Cancer
Main Authors: Conley-LaComb, M. Katie, Semaan, Louie, Singareddy, Rajareddy, Li, Yanfeng, Heath, Elisabeth I., Kim, Seongho, Cher, Michael L., Chinni, Sreenivasa R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093938/
https://ncbi.nlm.nih.gov/pubmed/27809841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0552-0
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