Activation state-dependent interaction between Gα(q) subunits and the Fhit tumor suppressor

BACKGROUND: The FHIT tumor suppressor gene is arguably the most commonly altered gene in cancer since it is inactivated in about 60% of human tumors. The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap(3)A. Despite the fact t...

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Detalhes bibliográficos
Main Authors: Zuo, Hao, Chan, Grace P W, Zhu, Jing, Yeung, Wendy W S, Chan, Anthony S L, Ammer, Hermann, Wong, Yung H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751744/
https://ncbi.nlm.nih.gov/pubmed/23947369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-59
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