Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

BACKGROUND: Cucurbitacins are a class of triterpenoid natural compounds with potent bioactivities that led to their use as traditional remedies, and which continue to attract considerable attention as chemical biology tools and potential therapeutics. One obvious target is the actin-cytoskeleton; tr...

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Main Authors: Gabrielsen, Mads, Schuldt, Maike, Munro, June, Borucka, Dagmara, Cameron, Jenifer, Baugh, Mark, Mleczak, Andrzej, Lilla, Sergio, Morrice, Nicholas, Olson, Michael F
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751690/
https://ncbi.nlm.nih.gov/pubmed/23945128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-58
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