Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

BACKGROUND: Cucurbitacins are a class of triterpenoid natural compounds with potent bioactivities that led to their use as traditional remedies, and which continue to attract considerable attention as chemical biology tools and potential therapeutics. One obvious target is the actin-cytoskeleton; tr...

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Autors principals: Gabrielsen, Mads, Schuldt, Maike, Munro, June, Borucka, Dagmara, Cameron, Jenifer, Baugh, Mark, Mleczak, Andrzej, Lilla, Sergio, Morrice, Nicholas, Olson, Michael F
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751690/
https://ncbi.nlm.nih.gov/pubmed/23945128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-58
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