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Kinetics of O(6)-Pyridyloxobutyl-2′-deoxyguanosine Repair by Human O(6)-alkylguanine DNA Alkyltransferase
Tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonicotine (NNN) are potent carcinogens believed to contribute to the development of lung tumors in smokers. NNK and NNN are metabolized to DNA-reactive species that form a range of nucleobase adducts, incl...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3750081/ https://ncbi.nlm.nih.gov/pubmed/23683164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4004952 |
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