Mass Spectrometry Based Approach to Study the Kinetics of O(6)-Alkylguanine DNA Alkyltransferase Mediated Repair of O(6)-pyridyloxobutyl-2′-deoxyguanosine Adducts in DNA

O(6)-POB-dG (O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]deoxyguanosine) are promutagenic nucleobase adducts that arise from DNA alkylation by metabolically activated tobacco-specific nitrosamines such as 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonicotine (NNN). If not repaired, O(6)-...

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Main Authors: Kotandeniya, Delshanee, Murphy, Dan, Seneviratne, Uthpala, Guza, Rebecca, Pegg, Anthony, Kanugula, Sreenivas, Tretyakova, Natalia
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221886/
https://ncbi.nlm.nih.gov/pubmed/21913712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx2002993
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