Kinetics of O(6)-Pyridyloxobutyl-2′-deoxyguanosine Repair by Human O(6)-alkylguanine DNA Alkyltransferase

Tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonicotine (NNN) are potent carcinogens believed to contribute to the development of lung tumors in smokers. NNK and NNN are metabolized to DNA-reactive species that form a range of nucleobase adducts, incl...

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Bibliographische Detailangaben
Hauptverfasser: Kotandeniya, Delshanee, Murphy, Daniel, Yan, Shuo, Park, Soobong, Seneviratne, Uthpala, Koopmeiners, Joseph S., Pegg, Anthony, Kanugula, Sreenivas, Kassie, Fekadu, Tretyakova, Natalia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750081/
https://ncbi.nlm.nih.gov/pubmed/23683164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4004952
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