The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway

The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances β-cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 di...

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Detalhes bibliográficos
Main Authors: ‘t Hart, Leen M., Fritsche, Andreas, Nijpels, Giel, van Leeuwen, Nienke, Donnelly, Louise A., Dekker, Jacqueline M., Alssema, Marjan, Fadista, Joao, Carlotti, Françoise, Gjesing, Anette P., Palmer, Colin N.A., van Haeften, Timon W., Herzberg-Schäfer, Silke A., Simonis-Bik, Annemarie M.C., Houwing-Duistermaat, Jeanine J., Helmer, Quinta, Deelen, Joris, Guigas, Bruno, Hansen, Torben, Machicao, Fausto, Willemsen, Gonneke, Heine, Robert J., Kramer, Mark H.H., Holst, Jens J., de Koning, Eelco J.P., Häring, Hans-Ulrich, Pedersen, Oluf, Groop, Leif, de Geus, Eco J.C., Slagboom, P. Eline, Boomsma, Dorret I., Eekhoff, Elisabeth M.W., Pearson, Ewan R., Diamant, Michaela
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749354/
https://ncbi.nlm.nih.gov/pubmed/23674605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0227
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