Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps

OBJECTIVE: At least 20 type 2 diabetes loci have now been identified, and several of these are associated with altered β-cell function. In this study, we have investigated the combined effects of eight known β-cell loci on insulin secretion stimulated by three different secretagogues during hypergly...

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Main Authors: ‘t Hart, Leen M., Simonis-Bik, Annemarie M., Nijpels, Giel, van Haeften, Timon W., Schäfer, Silke A., Houwing-Duistermaat, Jeanine J., Boomsma, Dorret I., Groenewoud, Marlous J., Reiling, Erwin, van Hove, Els C., Diamant, Michaela, Kramer, Mark H.H., Heine, Robert J., Maassen, J. Antonie, Kirchhoff, Kerstin, Machicao, Fausto, Häring, Hans-Ulrich, Slagboom, P. Eline, Willemsen, Gonneke, Eekhoff, Elisabeth M., de Geus, Eco J., Dekker, Jacqueline M., Fritsche, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797935/
https://ncbi.nlm.nih.gov/pubmed/19808892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0736
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