Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function

OBJECTIVE: Recently, results from a meta-analysis of genome-wide association studies have yielded a number of novel type 2 diabetes loci. However, conflicting results have been published regarding their effects on insulin secretion and insulin sensitivity. In this study we used hyperglycemic clamps...

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Autori principali: Simonis-Bik, Annemarie M., Nijpels, Giel, van Haeften, Timon W., Houwing-Duistermaat, Jeanine J., Boomsma, Dorret I., Reiling, Erwin, van Hove, Els C., Diamant, Michaela, Kramer, Mark H.H., Heine, Robert J., Maassen, J. Antonie, Slagboom, P. Eline, Willemsen, Gonneke, Dekker, Jacqueline M., Eekhoff, Elisabeth M., de Geus, Eco J., 't Hart, Leen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797936/
https://ncbi.nlm.nih.gov/pubmed/19833888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1048
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