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Impaired Tethering and Fusion of GLUT4 Vesicles in Insulin-Resistant Human Adipose Cells

Systemic glucose homeostasis is profoundly influenced by adipose cell function. Here we investigated GLUT4 dynamics in living adipose cells from human subjects with varying BMI and insulin sensitivity index (S(i)) values. Cells were transfected with hemagglutinin (HA)-GLUT4-green fluorescent protein...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lizunov, Vladimir A., Lee, Jo-Ping, Skarulis, Monica C., Zimmerberg, Joshua, Cushman, Samuel W., Stenkula, Karin G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749349/
https://ncbi.nlm.nih.gov/pubmed/23801575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1741
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