Impaired Tethering and Fusion of GLUT4 Vesicles in Insulin-Resistant Human Adipose Cells

Systemic glucose homeostasis is profoundly influenced by adipose cell function. Here we investigated GLUT4 dynamics in living adipose cells from human subjects with varying BMI and insulin sensitivity index (S(i)) values. Cells were transfected with hemagglutinin (HA)-GLUT4-green fluorescent protein...

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Main Authors: Lizunov, Vladimir A., Lee, Jo-Ping, Skarulis, Monica C., Zimmerberg, Joshua, Cushman, Samuel W., Stenkula, Karin G.
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2013
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749349/
https://ncbi.nlm.nih.gov/pubmed/23801575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1741
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