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Impaired Tethering and Fusion of GLUT4 Vesicles in Insulin-Resistant Human Adipose Cells

Systemic glucose homeostasis is profoundly influenced by adipose cell function. Here we investigated GLUT4 dynamics in living adipose cells from human subjects with varying BMI and insulin sensitivity index (S(i)) values. Cells were transfected with hemagglutinin (HA)-GLUT4-green fluorescent protein...

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Detalhes bibliográficos
Main Authors: Lizunov, Vladimir A., Lee, Jo-Ping, Skarulis, Monica C., Zimmerberg, Joshua, Cushman, Samuel W., Stenkula, Karin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749349/
https://ncbi.nlm.nih.gov/pubmed/23801575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1741
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